Alta Stomatology is an innovative oral disease research company dedicated to developing effective solutions for white sponge nevus. White Sponge Nevus is a rare mucosal leukokeratosis, occurring in less than 1 in 200,000 births, that can be transmitted in a dominant fashion in association with pathogenic variants of the KRT4 and KRT13 genes encoding keratin 4 and 13. At Alta Stomatology, we're dedicated to offering one-stop services for white sponge nevus/white folded disease research, including whole-genome sequencing, the development of novel therapies, and the molecular mechanisms behind this disorder. If you have any needs, please feel free to contact us.

Fig.1 Histological section of a White sponge nevus (Martelli H Jr, et al., 2006)

Research on White Sponge Nevus/White Folded Disease

White sponge nevus, also named as white folded disease, is an autosomal dominant condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by mutations in certain genes coding for keratin, resulting in a defect in the normal process of keratinization of the mucosa. The oral mucosa of patients is white or greyish, thickened, folded, and spongy. The onset is early in life, and both sexes are affected equally. Other common sites include the tongue, floor of the mouth, and alveolar mucosa.

The clinical manifestations are gray and white corrugated folds or furrows, in the shape of grass or wrinkled paper, and in a special pearlescent color or bright pink. The uneven surface may be present as small follicles with a soft texture. The mucous membrane can be removed with no pain or bleeding after swabbing. There are usually no obvious symptoms, but the change in mucosal texture and appearance may have a psychological impact on the patient. To develop better therapeutic strategies for white sponge nevus, it is important to understand the consequences of the associated genetic mutations and molecular changes.

Our Products

Our Services

At Alta Stomatology, we are committed to providing top-notch services in the field of oral disease research, specifically focusing on white sponge nevus and and its prevention and treatment. Elucidating the molecular mechanisms is a key factor for the development of successful treatments for white sponge nevus. Histological analysis can help us understand the morphological structure of the oral mucosa during the development of the disease.

Analysis Services

Customized Research Services

With the accumulated rich R&D experience and leading technology platform, Alta Stomatology can provide customers with high-quality "one-stop" technical services. For white sponge nevus diseases, we can offer a variety of customized research services, including: animal model establishment, drug screening & therapeutic efficacy testing, in vitro and in vivo study, novel drug delivery system, and oral organoid development.

Our Diagnosis Methods

At Alta Stomatology, we understand the importance of accurate diagnosis for effective treatment of white sponge nevus. That's why we have developed cutting-edge diagnosis methods to guide the diagnosis and assessment of the severity of oral mucosa disease.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service