Alta Stomatology is a leading oral disease research company that specializes in periapical granuloma and chronic periapical abscess research. We can provide you with the service for immunohistochemical and metabolomics analysis, 3D cell culture model establishment, and development of root canal filling materials. In addition, we offer custom research services that are critical to guiding chronic periapical periodontitis research efforts and developing targeted treatments. We are the ideal partner for combating chronic periapical periodontitis and improving oral health on a global scale, please feel free to contact us.

Fig.1 Diagrammatic representation of the possible pathogenesis of periodontal lesions (Nakahara Y, et al., 2014)

Research on Chronic Periapical Periodontitis

Chronic periapical periodontitis, also known as chronic apical periodontitis (CAP), refers to the chronic inflammation of periapical tissues due to the long-term presence of infection and pathogenic irritants in the root canal, which is manifested by the formation of inflammation and destruction of alveolar bone. Periapical granuloma is the main type of CAP, in which apical granulation tissue is produced around the root tip of the tooth, limiting bacteria to the original infected area and activating the immune system in response to inflammatory stimuli. Notably, periapical granuloma is the early stage of CAP, and its inflammatory response is more intense than that of periapical cysts. Chronic periapical abscess is another clinical feature of CAP, which is limited to periapical region.

CAP is an inflammatory disease with microbial etiology. Various microorganisms from the dental pulp cavity play leading roles in the development of AP. Typically, bacterial lipopolysaccharide leads to AP by stimulating a local immune response. When enamel or cementum is opened because of caries or trauma, oral microorganisms may enter the pulp cavity or root canal system from the crown or dentin canal and directly contact the pulp tissue or alveolar bone. However, bacteria that cause CAP are usually less toxic than those causing acute AP. If not treated in time, the chewing efficiency of the teeth will be reduced and the toothache will become worse. It may also cause alveolar bone osteomyelitis or other diseases.

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Most periapical infections are asymptomatic and the untreated inflammation usually develops gradually and is ongoing, referred to as chronic apical periodontitis. Chronic apical periodontitis refers to the chronic inflammation of periapical tissues caused by the long-term presence of infection and pathogenic irritants in the root canal, which is manifested by the formation of inflammation and destruction of alveolar bone. Uncontrolled infections often result in extensive bone loss around the root tip, which ultimately leads to tooth loss.

Customized Research Services

Alta Stomatology offers a comprehensive range of customized research services to address the specific needs of clients aiming to combat dental diseases. Our services include but are not limited to:

Why Choose Alta Stomatology?

• Cross-disciplinary Professional Team

Alta Stomatology has assembled a cross-disciplinary professional team, including clinical practitioners, scientists, researchers, and more in the field of oral health. This multidisciplinary collaborative approach enables the team to comprehensively and deeply investigate chronic periapical periodontitis from various perspectives, ensuring the thoroughness and depth of the research.

• Oral Field Expertise

The research team at Alta Stomatology possesses a wealth of expertise in the field of dentistry, with in-depth knowledge of oral anatomy, microbiology, biochemistry, and related disciplines. This allows them to have a comprehensive understanding of tooth structure and the oral environment, providing a solid foundation for delving into the pathogenesis of chronic periapical periodontitis.

• Cutting-Edge Technology

In the pursuit of unraveling the complexities of chronic periapical periodontitis, Alta Stomatology harnesses cutting-edge technology and methodologies. From advanced imaging techniques to genomic analyses, our commitment to staying at the forefront of scientific innovation ensures that our research is both comprehensive and pioneering.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service