Alta Stomatology is a leading oral disease research company that specializes in acute and chronic periapical periodontitis research. We can provide you with a one-stop service for the development of statins, immunohistochemical and metabolomics analysis, 3D cell culture model establishment, etc. Our mission is to improve oral health worldwide by developing effective therapies for periapical periodontitis. We are the ideal partner for combating periapical periodontitis and improving oral health on a global scale, please feel free to contact us.

Fig.1 Apical periodontitis, periapical abscess, and cellulitis (Douglass AB, et al., 2003)

Research on Periapical Periodontitis

Periapical periodontitis, more commonly known as apical periodontitis, is a prevalent infectious disease worldwide. Periapical periodontitis is most commonly a complication of untreated caries, pulpitis, dental trauma, inadequate root canal treatment or drug impairment. This is when there's some inflammation of the soft tissue that surrounds the tooth's root (the periodontium) due to bacteria in the tooth pulp. In addition to periapical abscesses, periapical periodontitis can give rise to various related lesions, including periapical granulomas and cysts.

Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to improve the success rate of treatment for apical periodontitis. Some of these approaches are still in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear.

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Apical periodontitis is an inflammatory response related to pathogens and their toxins occupying the root canal system. The pathogenic properties of bacteria, including antigenicity, mitogenic activity, chemotaxis, and enzymatic histolysis, as well as the body's defense mechanisms, such as immune cell products and intercellular messengers, play an active role in the inflammatory response, eventually leading to destruction of periapical tissues. Acknowledging the periapical health status of populations is essential for policymakers, as it will result in better management of resources for the prevention and treatment of periapical diseases.

Customized Research Services

Alta Stomatology offers a comprehensive range of customized research services to address the specific needs of clients aiming to combat dental diseases. Our services include but are not limited to:

Why Choose Alta Stomatology?

1. Customized and Scientific Support

Alta Stomatology offers multiple customized research services tailored to specific therapeutic needs. We provide technical support and collaborate closely with our clients to develop customized research plan and protocol.

2. Quality and Reliability

Alta Stomatology maintains a strong focus on the quality and reliability of research projects. We employ stringent quality control measures throughout the development process, from project design to data delivery.

3. Confidentiality and Intellectual Property Protection

We understand the importance of confidentiality and intellectual property protection. Alta Stomatology prioritizes the security and confidentiality of client information and maintains strict confidentiality agreements. We work closely with our clients to protect their intellectual property rights and ensure the confidentiality of their proprietary formulations and technologies.

• Organoid Development Service
• NDDS Development Service
• Animal Model Establishment Service